to end a broadcast on television or radio
Example: He settled at his desk and began to complete his own paperwork in time to sign off that of his subordinates before they sailed.
to end a conversation by radio or computer
Example: Hubert Conroy giving him this inflated opinion of himself didn't help Sel strike the right attitude when we went to sign off.
to end a letter
Example: Out he comes anyway into O'Connell Street, and underneath the coat he has this big bloody ice bucket, and a sign off the wall.
to give someone a medical certificate saying that they are too ill to work
Example: She signed off , ‘Yours sincerely, Clare Smith’.
to officially approve of something or to officially agree that something has been completed in a satisfactory way by signing your name
Example: The auditors signed off the accounts.