An insult or curse can be referred to as a piss. This word is not usually used in polite conversation.
When we talk about something that's useless or annoying, like a bad situation or a frustrating problem, we might call it a hassle or an annoyance, but if you were to use the word "piss" in this context, people would probably think you're being rude. But when we use "piss" as a verb, it means to urinate or go to the bathroom. This is its most common usage, and it's often used informally with friends or family.
(usually uncountable) Urine.
Example: This toilet is disgusting. There's piss all over the floor.
To urinate.
Example: When I got home I found a drunk pissing in my doorway.
