(Canada, US, informal) One who is left-handed.
(chiefly UK, informal, politics) One who has left-wing political views.
(slang) One's left testicle.
Example: I'll bet my lefty he won't show up for work today.
(MLE, slang, uncommon) One's left hand.
Is Chris Pratt a lefty?
Is Daniel Radcliffe's leg a lefty?